Archive for the 'Important Clinical Trials' Category

SF DPH to Offer PrEP

San Francisco will be the first city in the nation to offer PrEP treatment to HIV negative individuals. Read the article here.

Dr Conant’s Comments:

“I started offering preexposure prophylaxis to HIV-negative men who were at high risk of contracting HIV about six years ago. I had only about a dozen patients in that six year time frame, and most of them chose to stop taking the preexposure prophylaxis because their insurance companies would not pay for the medication and it was too expensive.

About 10 years ago Dr. Michael Youle and I approached senior management at Gilead to provide funding for an HIV preexposure prophylactic trial in high-risk men. Unfortunately, the company was not willing to pursue this initiative.

Recent trials have shown that preexposure prophylaxis if taken regularly significantly reduces the chance of contracting HIV. Studies have also shown that if HIV-positive patients are treated and can maintain an undetectable viral load they are at little or no risk to infecting their sexual partners.

It appears to me that the way to stop the HIV/AIDS epidemic in San Francisco is to test everyone for HIV, treat everyone who is HIV-positive the moment they are found to be positive, and then monitor those patients through the Public Health Service to be certain that they maintain an undetectable viral load.

This use of resources would significantly diminish HIV transmission, allow for contact tracing, keep HIV positive people  healthier and decrease transmission. The cost of this program would be more than the cost of prescribing pre-exposure prophylaxis to a few patients, but would be far more effective in reducing the number of HIV infections in the city and in the long run far more cost-effective.

I am pleased to see that San Francisco is going to be a test site for preexposure prophylaxis. I’m anxious to see who is going to pay for this program long  term.”

Study: Prevention of HIV-1 Infection with Early Retroviral Therapy

Dr Conant’s comments:

The results of this study unequivocally confirm the argument that I have been making for the past three years. We need to test everyone to find out who is positive. At the present time more than one third of the people infected with HIV do not know that they are infected. We then need to treat everyone as soon as they test positive. This should be a government responsibility. The funds were used to treat individuals with tuberculosis and syphilis to stop the transmission of these to communicable diseases. To do less for HIV/AIDS is unconscionable.  Right now one third of individuals who are HIV-positive and know that they are positive are not on treatment. Finally, the public health service should be used to determine why HIV-positive individuals are not taking their medications and to offer interventions to assist them with compliance both for their own health and the health of the nation.

NEJM Article from July 18, 2011:  Prevention of HIV-1 Infection with Early Antiretroviral Therapy, July 18, 2011

NEJM Editorial from July 18, 2011:  Antiretroviral Treatment as Prevention

HIVers needed for flu remedy study

Source:  The Bay Area Reporter

01_09_Flu_46_LRG

Dr. Jay Lalezri, Alan McCord, Dr. Lawrence Drew, Dr. Michael Harbour, and Dr. Marcus Conant discuss this year's flu season and the availability for HIV-positive people to enroll in a study for a new combination drug. Photo: Jane Philomen Cleland

“This flu season people living with HIV who contract influenza are being asked to test a new triple combination antiviral drug (TCAD) therapy that may work better in treating their symptoms and lessening the severity of their illness.

Anyone who is HIV-positive and experiencing flu-like symptoms, such as a fever of 100 degrees Fahrenheit or higher, headaches, or fatigue in combination with cough, sore throat, congestion, or muscle aches, can call a hotline to determine if they meet the criteria for the study.”

Click here to read more.

Duo Project

Source:  UCSF

Are you in a male couple relationship?  Are you or your partner on HIV meds?

Call today to find out if you and your partner are eligible to participate in interviews about HIV related issues and earn up to $120 per couple visit!

For more information, please call (877) DUO-6292, or (415) 597-9322.

HIV+Flu?

ConantFluGloss9Source:  The Conant Medical Group

Enrolling now, a research study of a new investigational flu treatment.

Requirements:

  • 18 to 65 years of age
  • HIV+ with less than 500 T-cells
  • Fever over 100 degrees, with any or all of the following symptoms:  cough, sore throat, muscle ache or headache

All study visits, medical procedures and laboratory tests will be provided at no cost to qualified participants.

Qualified participants will be compensated for time and travel.

For more information, please call the Conant Medical Group at 415-575-7500, or email Chris Eden, M.D. at ceden@conantmedical.org


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